龙功果 / 杜古 / 榔色果 / 兰萨果 — Lansium parasiticum (Osbeck) K.C.Sahni & Bennet (syn. Lansium domesticum)

Pinyin: Lónggōngguǒ / Dùgǔ / Lángsèguǒ · Malay: Langsat / Duku / Duku Langsat / Dokong · Family: Meliaceae (楝科)

Energetics

Cool to Cold (凉 / 微寒)

Flavor

Bitter, intensely astringent, slightly sweet (苦、涩、微甘)

Meridians

Large Intestine (大肠), Liver (肝), Stomach (胃)

Traditional Edict

Royal tribute fruit. Bitter seeds and bark clear toxic heat, terminate malarial pestilence (Demam Kura), stop chronic bloody dysentery, and kill intestinal parasites. Dried peel burned as mosquito smudge.

Cautions & Contraindications

Green seeds are intensely bitter; encapsulate for oral administration. Contraindicated in Spleen-Stomach deficiency cold diarrhea without heat-toxin.

Clinical Applications

Chloroquine-resistant falciparum malaria, acute bacillary dysentery (Shigella), intestinal helminthiasis, multidrug-resistant cancer adjuvant, and mosquito vector repelling.

Quality Markers

Lamesticumin A-E (Cycloartane Triterpenes >= 0.50%) & Oncorhynchol (HPLC MHM standard)

Mechanism & Phytochemistry

1. Lamesticumins and cycloartane triterpenes disrupt Plasmodium falciparum food vacuole and hemozoin crystallization (IC50 0.2-2.5 ug/mL). 2. Lansiosides downregulate cAMP-mediated gut fluid secretion. 3. Volatile resins in dried peel paralyze mosquito antennae.

Preparation & Dosage

Sliced dried green seeds (Biji Langsat) decocted: 3-6 g daily (intensely bitter). Dried stem bark: 10-20 g. Dried peel burned as mosquito smudge. Standardized extract: 150-300 mg.

Appended Prescriptions

1. Nanyang Sovereign Anti-Malarial Febrifuge with Tinospora crispa (Patawali) and Andrographis paniculata. 2. Rainforest Dysentery Synergy with Psidium guajava leaves.

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Yemama Apothecary · Petaling Jaya, Malaysia · For educational and clinical reference only