白花蛇舌草 / 蛇舌草 / 二叶葎 — Hedyotis diffusa Willd. (syn. Oldenlandia diffusa)

Pinyin: Báihuā Shéshécǎo / Shéshécǎo · Malay: Rumput Lidah Ular / Bayam Rusa · Family: Rubiaceae (茜草科)

Energetics

Cool to Cold (微寒 / 寒)

Flavor

Bitter, sweet, bland (苦、甘、淡)

Meridians

Stomach (胃), Large Intestine (大肠), Small Intestine (小肠), Liver (肝)

Traditional Edict

Clears toxic heat, purges fire, disperses abscesses and dissolves nodules, drains dampness and unblocks strangury. Sovereign remedy for internal organ abscesses (appendicitis), acute hepatitis, snakebites, and malignant tumors.

Cautions & Contraindications

Clear cold nature; prolonged high-dose use can weaken Spleen Yang. Contraindicated in Spleen-Stomach deficiency cold diarrhea and pregnancy.

Clinical Applications

Colorectal carcinoma, gastric adenocarcinoma, hepatocellular carcinoma, ER-positive breast cancer, acute appendicitis, pelvic inflammatory disease, and UTIs.

Quality Markers

Asperuloside (车叶草苷) >= 0.15% & Oleanolic/Ursolic Acid >= 0.10% (Chinese Pharmacopoeia)

Mechanism & Phytochemistry

1. Oleanolic acid and ursolic acid upregulate p53 expression, activate Caspase-3/9 apoptotic cascades, and suppress VEGF-induced tumor angiogenesis. 2. Asperuloside and scandoside downregulate NF-kB and MAPK pathways in colorectal lines. 3. Polysaccharides stimulate CD4+/CD8+ T-lymphocyte proliferation.

Preparation & Dosage

Dried whole herb in decoction: 15-30 g daily (up to 60-120 g in oncology regimens). Standardized extract: 500-1000 mg twice daily.

Appended Prescriptions

1. Classical Oncology & Toxin-Purging Synergy with Scutellaria barbata (Ban Zhi Lian) for colorectal and hepatocellular tumor support. 2. Intestinal Abscess Appendicitis Decoction with Rheum officinale and Paeonia suffruticosa.

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Yemama Apothecary · Petaling Jaya, Malaysia · For educational and clinical reference only