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    Yemama Apothecary

    Bencao Gangmu Reference Library

    Astringent, Dysentery-Clearing, Hemostatic & Anti-Inflammatory (涩肠止泻 / 清热解毒收敛生肌止血药)

    山竹壳 / 莽吉柿 / 倒捻子壳 — Garcinia mangostana L.

    Pinyin: Shānzhúké / Mǎngjíshì · Malay: Kulit Manggis / Manggis · Family: Clusiaceae (藤黄科)

    Botanical Illustration

    Energetics

    Cool to Cold (凉 / 微寒)

    Flavor

    Bitter, astringent, sour (苦、涩、酸)

    Meridians

    Large Intestine (大肠), Stomach (胃), Liver (肝)

    Traditional Edict

    Clears toxic heat, dries dampness, astringes intestines to stop chronic dysentery, stops bleeding, and knits wounds. Queen of Tropical Fruits pericarp for colitis, ulcers, and acne.

    Cautions & Contraindications

    • High astringency; do not use in early infectious dysentery before toxins are cleared. Contraindicated in chronic spastic constipation.

    Clinical Applications

    • Chronic ulcerative colitis, irritable bowel syndrome (IBS-D), MRSA skin infections, cystic acne vulgaris (Cutibacterium acnes), and colon cancer adjuvant.

    Quality Markers

    a-Mangostin (a-倒捻子素) >= 20.00% & g-Mangostin via HPLC (MHM standard)

    Mechanism & Phytochemistry

    1. a-Mangostin directly inhibits COX-2 and 5-LOX selectively without suppressing COX-1, downregulating TNF-a, IL-1b, and IL-6. 2. Destroys bacterial cell membranes of MRSA and C. acnes (MIC 0.78-1.56 ug/mL). 3. Induces mitochondrial Caspase-3/9 apoptosis in colon cancer.

    Preparation & Dosage

    Dried sliced pericarps decocted 20 minutes: 6-15 g daily. Topical wash for weeping eczema and hemorrhoids: 20-30 g boiled in 1 L water. Standardized extract: 250-500 mg.

    Appended Prescriptions

    • 1. Nanyang Sovereign Anti-Dysenteric & Colitis Decoction with Helicteres isora (Cabai Tali) and Coptis chinensis. 2. Topical Anti-Acne Salve with Piper betle (Sirih) and Virgin Coconut Oil.

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    Yemama Apothecary · Petaling Jaya, Malaysia · For educational and clinical reference only