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    Yemama Apothecary

    Bencao Gangmu Reference Library

    Heat-Clearing, Nodule-Dissolving & Anti-Neoplastic Sovereign (清热解毒 / 软坚散结消肿抗癌降压药)

    刺果番荔枝 / 红毛榴莲 / 刺番荔枝 — Annona muricata L.

    Pinyin: Cìguǒ Fānlìzhī / Hóngmáo Liúlián · Malay: Durian Belanda / Durian Makkah / Nona Belanda · Family: Annonaceae (番荔枝科)

    Botanical Illustration

    Energetics

    Cool (微凉 / 凉)

    Flavor

    Sour, sweet, slightly astringent (酸、甘、微涩)

    Meridians

    Stomach (胃), Liver (肝), Large Intestine (大肠)

    Traditional Edict

    Clears toxic heat, dissolves hard nodules and softens masses, calms Liver to lower blood pressure, relieves stomach heat. Premier Nanyang anti-cancer longevity leaf for tumors, hypertension, and diabetes.

    Cautions & Contraindications

    • SEED AND HIGH-DOSE CHRONIC PRECAUTION: Seeds and excessive chronic use contain neurotoxic annonacin associated with atypical parkinsonism. NEVER INGEST SEEDS. Apply cycled washout phases.

    Clinical Applications

    • Adjuvant oncology management of breast carcinoma (MCF-7), colorectal cancer (HCT-116), prostate cancer (PC-3), primary essential hypertension, and osteoarthritis.

    Quality Markers

    Annonaceous Acetogenins (Annonacin, Bullatacin) >= 0.10% & Rutin (HPLC MHM standard)

    Mechanism & Phytochemistry

    1. Annonacin and polyketide acetogenins potently inhibit mitochondrial Complex I (NADH dehydrogenase), depleting ATP in chemoresistant tumor cells and triggering apoptosis. 2. Rutin and coreximine stimulate eNOS and block calcium channels, reducing blood pressure. 3. Downregulates NF-kB.

    Preparation & Dosage

    Dried Leaf Tisane (Daun Durian Belanda Tea): 5 to 10 dried leaves boiled 15 minutes: 5-15 g daily. Standardized extract: 250-500 mg. CYCLED USE: 4 weeks on, 2 weeks off (washout period).

    Appended Prescriptions

    • 1. Nanyang Anti-Neoplastic & Nodule-Resolving Synergy with Clinacanthus nutans (You Dun Cao) and Hedyotis diffusa. 2. Cardiovascular Blood-Pressure Calming Formula with Orthosiphon and Roselle.

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    Yemama Apothecary · Petaling Jaya, Malaysia · For educational and clinical reference only